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 For the study of Salmonella pathogenesis, we employ the extensively used mouse model. In mice, the so-called “serovar Typhimurium” of Salmonella enterica causes a disease similar to human typhoid fever. To investigate the mechanisms by which Salmonella causes disease, we combine classical genetics and molecular biology. |
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The genetics of Salmonella was born in the 1950s, when Norton Zinder and Joshua Lederberg described generalized transduction of host DNA mediated by bacteriophage P22. In the following decades, John Roth and other investigators have turned P22 into a sophisticated toolbox for Salmonella genetics. Sometimes, the main limit to the experiments that can be done is the investigator’s imagination. This is highly stimulating for graduate students, and rewarding for all investigators. In turn, the molecular biology of Salmonella benefits from the enormous array of technical procedures devised for E. coli. |
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